Enzymes & Biomarkers

ADAMTS-5

Written by Peptok ResearchReviewed by Medical Advisory BoardLast updated: Jan 2026

Quick Stats

Evidence Strength3/10 (Low)

Based on number and quality of indexed studies

Community Popularity5/10 (Moderate)

Based on search volume and community interest

Legal Status

⚖️ Unregulated (US)

Type

Enzymes & Biomarkers

Route

Injection

Half-life

N/A (endogenous enzyme)

Overview Benefits & Evidence Who It's For Dosage Guide Community Safety Profile Research FAQ References

Medical Disclaimer

This content is for informational and research purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before making decisions about peptide use or any medical treatment. Individual results may vary.

Overview

An enzyme (aggrecanase-2) involved in cartilage degradation. Research focuses on osteoarthritis treatment and inflammatory conditions.

Quick Summary

🧬
What it is:An enzyme (aggrecanase-2) involved in cartilage degradation.
🎯
Primary use:Enzymes & Biomarkers applications — see benefits section for details.
📊
Evidence level:Preliminary — Mostly anecdotal or very early-stage research (0 indexed papers)
✅
Bottom line:Very early research phase. Approach with appropriate caution; long-term safety is unknown.

ADAMTS-5

⚠️ NOTE: ADAMTS-5 is an enzyme (protease), not a peptide. It is also known as aggrecanase-2.

What is ADAMTS-5?

ADAMTS-5 (A Disintegrin And Metalloproteinase with Thrombospondin motifs 5) is a member of the ADAMTS family of metalloproteinases. It plays a crucial role in breaking down aggrecan, a major component of cartilage.

Research Status

ADAMTS-5 is being actively studied as a therapeutic target for osteoarthritis. Inhibiting ADAMTS-5 may help protect cartilage from degradation.

Mechanism of Action

ADAMTS-5 cleaves aggrecan at specific sites, leading to cartilage breakdown. This makes it a key target for osteoarthritis drug development.

Difference from Peptides

Unlike peptides (which are small proteins), ADAMTS-5 is a larger enzyme (~987 amino acids) that catalyzes proteolytic reactions. Peptide supplements do not include ADAMTS-5.

Benefits & Evidence

Cartilage degradation biomarker

Moderate Evidence

1 studies · 0 human trials

Osteoarthritis research target

Preliminary

1 studies · 0 human trials

Joint health indicator

Preliminary

1 studies · 0 human trials

Who Uses ADAMTS-5?

Research enthusiasts

Preliminary

Emerging therapeutic applications being studied

Biohackers

Anecdotal

Exploring optimization potential

Not recommended if:

Pregnant or nursing, history of hormone-sensitive cancers, active autoimmune conditions, or pediatric patients. Always consult a physician before starting any peptide protocol.

Dosage Guide

Protocol by Experience Level

Experience	Dose	Frequency	Cycle	Route
Beginner	100 mcg	Daily or EOD	4–6 wks, 2 wks off	SubQ injection
Intermediate	300 mcg	Daily	4–6 wks, 2 wks off	SubQ injection
Advanced	500 mcg	Daily (split dose)	4–6 wks, 2 wks off	SubQ injection

Standard Protocol

N/A

Route

Subcutaneous

Half-life

N/A (endogenous enzyme)

Molecular Weight

N/A

Disclaimer

This information is for educational purposes only. Dosage information is derived from research literature and community reports. Always consult a qualified healthcare provider before using any peptide.

What the Community Reports

Community data coming soon

We're aggregating Reddit discussions for ADAMTS-5.

Safety Profile

Regulatory Status

⚠️ Not FDA approved — for research use. Unregulated in US.

Common

Not used as a therapeutic — it is an enzyme/biomarker

Rare

Dizziness
Headache

Serious

No serious adverse events reported in available literature.

Pregnancy: ❌ Not recommended — no safety dataKnown Interactions: 0 documented stacks

Available

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Research

Mechanism of Action

ADAMTS-5 is an aggrecanase enzyme that cleaves aggrecan in cartilage. Elevated levels indicate cartilage breakdown and are used as a biomarker for osteoarthritis progression.

No research papers indexed for this compound yet.

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